In plain English
HGH Fragment 176-191 is the last 16 amino acids of human growth hormone, the part linked to burning fat. It is used for fat loss without growth hormone’s effects on blood sugar, IGF-1 or muscle growth. AOD-9604 is a slightly modified version of it.
What it's used for
- Fat loss, especially stubborn fat
- Body recomposition alongside diet and training
Benefits
In animal studies, this fragment increased fat breakdown and reduced fat storage without raising blood sugar or IGF-1. Users report gradual fat loss, especially around the waist, when combined with diet and exercise.
How it works
In simple terms: it keeps growth hormone’s fat-burning signal and leaves out the rest.
The 176–191 region of growth hormone stimulates the breakdown of stored fat and reduces new fat formation in fat cells, without activating the growth hormone receptor in the usual way.
Development history
- 1990s: Researchers at Monash University identify the fat-burning region of growth hormone.
- Later: The modified version, AOD-9604, is taken into human trials; the unmodified fragment remains popular with users.
Typical protocols
These ranges are what users commonly report.
| Use | Dose | Frequency | Length |
|---|---|---|---|
| Fat loss | 250–500 mcg | 1–2 times daily, fasted (morning and/or before training) | 8–12 weeks |
Cycling
Commonly run for 8–12 weeks, then a break.
Administration options
Subcutaneous injection, often in the belly.
Reconstitution and dosing calculator
Usually comes in 2 mg or 5 mg vials, mixed with 2 mL of bacteriostatic water.
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This tool does arithmetic only. It does not choose a dose or confirm that any substance is right for you. Double-check every result against your syringe and your clinician’s instructions.
Side effects and safety
- Users report that it is generally well tolerated. Occasional effects include injection-site redness and headache.
- Long-term effects have not been well studied.
- Avoid during pregnancy and breastfeeding.
Common stacks
- CJC-1295 and ipamorelin: combined for body composition.
- GLP-1 peptides: combined by some users for fat loss.
Storage
Powder: refrigerate. After mixing: refrigerate at 2–8 °C and use within about 3–4 weeks.
Compare with
- AOD-9604: the same fragment with one amino acid added for stability, and with human safety data.
- Tesamorelin: raises your own growth hormone, with strong data for belly fat.
Frequently asked questions
Fragment 176-191 or AOD-9604?
They are nearly the same. AOD-9604 has an added amino acid for stability and has been tested in people; users report similar results from both.
Why take it fasted?
Insulin from food works against fat breakdown, so users take it on an empty stomach.
References
- Ng FM, et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-278.