In plain English
Adipotide is a peptide designed to find the blood vessels that feed white fat and shut them down. Without a blood supply, the fat tissue shrinks. It is one of the most aggressive approaches to fat loss and also one of the riskiest.
What it's used for
- Fat loss (experimental)
- Originally explored for cancer
Benefits
In animal studies, obese monkeys lost about 11% of their body weight over four weeks, with a large drop in belly fat and better insulin sensitivity. Users report rapid fat loss, often alongside kidney concerns.
How it works
In simple terms: it cuts off the blood supply to fat.
One part of the peptide binds prohibitin, a protein found on the blood vessels that feed white fat. The other part damages the membranes of those vessel cells, causing them to die. The fat tissue then shrinks and is reabsorbed.
Development history
- 2004: First described in mice by researchers at MD Anderson Cancer Center.
- 2011: Monkey study shows significant weight loss and also kidney effects.
- Later: An early human study in prostate cancer is started; development stalls.
Typical protocols
There is no established human dose. Users commonly report the following, usually with kidney monitoring.
| Use | Dose | Frequency | Length |
|---|---|---|---|
| Fat loss | About 1–2 mg | Daily | 2–4 weeks |
Cycling
Short courses only, with long breaks and kidney checks.
Administration options
Subcutaneous injection.
Reconstitution and dosing calculator
Usually comes in 2 mg, 5 mg or 10 mg vials, mixed with 2 mL of bacteriostatic water.
Draw your syringe to
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Show the math
This tool does arithmetic only. It does not choose a dose or confirm that any substance is right for you. Double-check every result against your syringe and your clinician’s instructions.
Side effects and safety
- Kidney strain and damage were seen in animal studies; these were dose-related and reversible after stopping.
- Dehydration, fatigue and injection-site reactions.
- Not suitable for anyone with kidney problems.
- Avoid during pregnancy and breastfeeding.
Common stacks
Usually used alone, given its risks.
Storage
Powder: refrigerate or freeze. After mixing: refrigerate at 2–8 °C and use within about 3 weeks.
Compare with
- GLP-1 medicines: reduce appetite and have far more human data.
- AOD-9604 and HGH Fragment 176-191: gentler fat-burning peptides.
Frequently asked questions
Is adipotide safe?
It has not been tested enough in people to say. Kidney effects in animals are the main concern.
References
- Kolonin MG, et al. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004;10(6):625-632.
- Barnhart KF, et al. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011;3(108):108ra112.