In plain English
5-Amino-1MQ is not technically a peptide but a small molecule, sold alongside peptides. It blocks NNMT, an enzyme that is overactive in fat tissue. Blocking it is thought to make fat cells burn more energy and to raise NAD+, a molecule cells need for energy.
What it's used for
- Fat loss
- Metabolic health
- Cell energy and NAD+ support
Benefits
In animal studies, mice on a high-fat diet given 5-Amino-1MQ lost body weight and fat, had smaller fat cells and better cholesterol, without eating less. Users report gradual fat loss and more energy.
How it works
In simple terms: it switches off an enzyme that makes fat cells sluggish.
NNMT uses up methyl groups and NAD+ precursors in fat cells. Blocking it raises NAD+ and SAM (a key methyl donor), which shifts fat cells toward burning energy and away from storing fat.
Development history
- 2010s: Researchers link high NNMT in fat to obesity and diabetes.
- 2018: Mouse study shows weight and fat loss with 5-Amino-1MQ (University of Texas Medical Branch).
Typical protocols
There is no established human dose. Doses vary widely; these ranges are what users commonly report.
| Use | Dose | Frequency | Length |
|---|---|---|---|
| Fat loss | 5–10 mg | Daily | 4–8 weeks |
Cycling
Commonly run for 4–8 weeks, then a break.
Administration options
Subcutaneous injection.
Reconstitution and dosing calculator
Usually comes in 50 mg vials, mixed with 2–5 mL of bacteriostatic water.
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This tool does arithmetic only. It does not choose a dose or confirm that any substance is right for you. Double-check every result against your syringe and your clinician’s instructions.
Side effects and safety
- Users report it is generally well tolerated; mild nausea, headache or trouble sleeping are mentioned.
- No formal safety data in people.
- Avoid during pregnancy and breastfeeding.
Common stacks
- NAD+: often paired for cell energy.
- GLP-1 peptides: combined by some users for fat loss.
Storage
Powder: refrigerate or freeze. After mixing: refrigerate at 2–8 °C and use within about 4 weeks.
Compare with
- NAD+: supplies NAD+ directly.
- MOTS-c: another compound studied for metabolism and fat loss.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No. It is a small molecule, but it is sold and discussed alongside peptides.
References
- Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152.