In plain English
SLU-PP-332 is a small molecule, sold alongside peptides, that switches on ERR proteins, the same switches exercise flips to build endurance. In mice it made muscles behave as if they had been trained, burning more fat and running longer.
What it's used for
- Endurance and stamina
- Fat loss
- Metabolic health
Benefits
In animal studies, mice given SLU-PP-332 ran about 70% longer and 45% farther than untreated mice, and obese mice lost fat and improved blood sugar without changing their diet. Users report more stamina and gradual fat loss.
How it works
In simple terms: it tells muscles to act trained.
It activates estrogen-related receptors (ERRα, β and γ), which turn on genes for building mitochondria and burning fat. Muscles shift toward endurance-type fibers. Despite the name, these receptors do not respond to estrogen.
Development history
- 2023: First results published by Thomas Burris’s group at Saint Louis University (the “SLU” in its name).
- 2024: Further mouse studies on obesity and metabolism.
Typical protocols
There is no established human dose. These ranges are what users commonly report.
| Use | Dose | Frequency | Length |
|---|---|---|---|
| Endurance and fat loss | 250 mcg–1 mg | Daily | 4–8 weeks |
Cycling
Commonly run for 4–8 weeks, then a break.
Administration options
Subcutaneous injection.
Reconstitution and dosing calculator
Usually comes in 5 mg or 10 mg vials. It does not dissolve easily in water; follow the seller’s mixing instructions.
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This tool does arithmetic only. It does not choose a dose or confirm that any substance is right for you. Double-check every result against your syringe and your clinician’s instructions.
Side effects and safety
- Users report increased heart rate, feeling warm or restless, and trouble sleeping.
- No formal safety data in people.
- Avoid during pregnancy and breastfeeding.
- Likely to be treated as prohibited in competitive sport, like other exercise mimetics.
Common stacks
- MOTS-c: another exercise-mimicking compound.
- GLP-1 peptides: combined by some users for fat loss.
Storage
Powder: refrigerate or freeze. After mixing: refrigerate at 2–8 °C and use within about 3 weeks.
Compare with
- MOTS-c: a mitochondrial peptide that also mimics exercise.
- 5-Amino-1MQ: a different small molecule studied for fat loss.
Frequently asked questions
Can it replace exercise?
In mice it copied some effects of endurance training. It has not been tested in people, and training has many benefits it does not reproduce.
References
- Billon C, et al. Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023;18(4):756-771.